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Literature summary for 2.4.2.30 extracted from
- Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage (2016), Cell Chem. Biol., 23, 1251-1260 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli Rosetta2 (DE3) cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G888W | inactive | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-aminobenzamide | - |
Homo sapiens |  |
| 4-[4-(1-aminoethenyl)phenoxy]benzamide | OUL35, potent inhibitor of ARTD10 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q53GL7 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography, heparin column chromatography, and gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ARTD10 | - |
Homo sapiens |
| mono-ADP-ribosyltransferase | - |
Homo sapiens |
| PARP10 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000329 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[4-(1-aminoethenyl)phenoxy]benzamide | |
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